Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 232, Issue 6, Pages 715-726Publisher
SOC EXPERIMENTAL BIOLOGY MEDICINE
Keywords
P1 receptors; P2 receptors; adenosine; ATP; renal microvasculature; renal autoregulation
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Funding
- NHLBI NIH HHS [HL074167, P01 HL074167] Funding Source: Medline
- NIDDK NIH HHS [DK44628, R01 DK044628] Funding Source: Medline
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The multiple roles of extracellular ATP and its metabolite adenosine include broad areas, such as regulating vascular tone and inducing inflammation. This review will discuss purinoceptor-induced effects on renal vascular resistance, highlighting the key experiments providing a significant contribution to our current understanding of autoregulatory mechanisms. Emphasis will be placed on the purinoceptor subtypes involved in autoregulatory control by ATP and adenosine. Additionally, the role of purinoceptors in hypertension-associated impairment of autoregulatory efficiency will be discussed.
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