Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 17, Issue 3, Pages 325-330Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2007.03.013
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Funding
- NIA NIH HHS [P01AG17490, AG025970] Funding Source: Medline
- NICHD NIH HHS [HD23315] Funding Source: Medline
- NINDS NIH HHS [NS21072, NS049442] Funding Source: Medline
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The growing realization that neurotrophins, such as brain-derived neurotrophic factor (BDNF), are crucial in modulating synaptic plasticity has broadened the spectrum of their trophic actions. At the same time, it has become clear that A beta peptides derived from amyloid precursor protein (APP) have dramatic effects on synaptic transmission before the onset of the neurodegenerative disease. Because neurotrophins and A beta are responsible for affecting both synaptic and cognitive function, it is likely that their mechanisms of action will be related and might even intersect. This review highlights several recent findings that suggest trophic factors and APP use similar pathways to control neuronal activity.
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