Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 12, Pages 28566-28581Publisher
MDPI
DOI: 10.3390/ijms161226120
Keywords
parallel reaction monitoring; PRM; selected reaction monitoring; SRM; proteomics; mass spectrometry; targeted; quantitative proteomics; Q-Exactive; high resolution; accurate mass
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The parallel reaction monitoring (PRM) assay has emerged as an alternative method of targeted quantification. The PRM assay is performed in a high resolution and high mass accuracy mode on a mass spectrometer. This review presents the features that make PRM a highly specific and selective method for targeted quantification using quadrupole-Orbitrap hybrid instruments. In addition, this review discusses the label-based and label-free methods of quantification that can be performed with the targeted approach.
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