Journal
APPLIED SPECTROSCOPY
Volume 61, Issue 6, Pages 579-584Publisher
SOC APPLIED SPECTROSCOPY
DOI: 10.1366/000370207781269747
Keywords
in vivo Raman spectroscopy; micro-Raman probe; miniaturized endoscope; esophagus; stomach
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A small endoscope system equipped with a micro Raman probe is developed for in vivo Raman measurements in living rats. The measurements are done under anesthesia and artificial respiration to minimize the impact on the rats. Raman spectra of living rat esophagus and stomach are successfully measured. Our results suggest that the Raman spectra reflect subsurface tissue structure that cannot be distinguished in the endoscope image. After the experiments, rats recover without any aftereffects. It is verified that the Raman measurement using the present system is safe and noninvasive for rats.
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