Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 85, Issue 6, Pages 416-420Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/V07-051
Keywords
silica chloride; indole; carbonyl compound; solvent-free; bis(indolyl)methane
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A simple and efficient solvent-free procedure for the preparation of bis(indolyl)methanes via electrophilic substitution reactions of indoles with aldehydes and ketones is described. The reactions took place in the presence of a catalytic amount of silica chloride at room temperature. The advantages of this method are high yields, short reaction times, low cost, and compliance with green-chemistry protocols.
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