Journal
NUTRITION REVIEWS
Volume 65, Issue 6, Pages S39-S46Publisher
INT LIFE SCIENCES INST NORTH AMERICA
DOI: 10.1301/nr.2007.jun.S39-S46
Keywords
insulin resistance; lipid; mediators; obesity
Categories
Funding
- NIDDK NIH HHS [DK073181, DK070565, DK58784] Funding Source: Medline
Ask authors/readers for more resources
Lipid abnormalities such as obesity, increased circulating free fatty acid levels, and excess intramyocellular lipid accumulation are frequently associated with insulin resistance. These observations have prompted investigators to speculate that the accumulation of lipids in tissues not suited for fat storage (e.g., skeletal muscle and liver) is an underlying component of insulin resistance and the metabolic syndrome. We review the metabolic fates of lipids in insulin-responsive tissues and discuss the roles of specific lipid metabolites (e.g., ceramides, GM3 ganglioside, and diacylglycerol) as antagonists of insulin signaling and action.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available