Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 10, Pages 24629-24655Publisher
MDPI
DOI: 10.3390/ijms161024629
Keywords
atypical parkinsonism; multiple system atrophy; dementia with Lewy bodies; progressive supranuclear palsy; corticobasal degeneration
Funding
- Intramural Research Program of the U.S. National Institutes of Health, National Institute of Neurological Disorders and Stroke
- National Institute of Neurological Disorders and Stroke [R25 NS065729]
- Alzheimer's Society Research Fellowship
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Atypical parkinsonism syndromes, such as dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, are neurodegenerative diseases with complex clinical and pathological features. Heterogeneity in clinical presentations, possible secondary determinants as well as mimic syndromes pose a major challenge to accurately diagnose patients suffering from these devastating conditions. Over the last two decades, significant advancements in genomic technologies have provided us with increasing insights into the molecular pathogenesis of atypical parkinsonism and their intriguing relationships to related neurodegenerative diseases, fueling new hopes to incorporate molecular knowledge into our diagnostic, prognostic and therapeutic approaches towards managing these conditions. In this review article, we summarize the current understanding of genetic mechanisms implicated in atypical parkinsonism syndromes. We further highlight mimic syndromes relevant to differential considerations and possible future directions.
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