Journal
NANO LETTERS
Volume 7, Issue 6, Pages 1609-1612Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl0705438
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Funding
- NIBIB NIH HHS [EB002189, R01 EB002189-07, R01 EB002189] Funding Source: Medline
- NIGMS NIH HHS [GM07178] Funding Source: Medline
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The inner walls of gold nanotubes, prepared by template synthesis in the nanopores of polycarbonate track etch membranes, have been chemically modified with peptide nucleic acid (PNA) and used for label-free quantification of complementary DNA sequences. Selective binding of DNA to the PNA-modified nanotubes is shown to decrease the flux of optically detected anionic markers through the nanotubes in a concentration-dependent manner. The strong dependence of the biorecognition-modulated ion transport through the nanopores on the ionic strength suggests a dominantly electrostatic exclusion mechanism of the ion flux decrease as a result of DNA binding to the PNA-modified nanopores.
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