Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 4, Pages 7493-7519Publisher
MDPI
DOI: 10.3390/ijms16047493
Keywords
gut bacteria; human health; cancer; obesity
Funding
- National Natural Science Foundation of China [81372976]
- Sun Yat-sen University
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Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 10(14) microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function. However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism. This review summarizes and discusses the roles and potential mechanisms of gut bacteria in human health and diseases.
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