Journal
HAEMATOLOGICA
Volume 92, Issue 6, Pages 861-862Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10914
Keywords
acute myeloid leukemia; transcription factor; AML1 mutation; leukemogenesis; cooperative events
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Funding
- Siriraj Chalermprakiat Fund
- Mahidol University
- National Research Council of Thailand
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AML1 mutations were identified in 6.3% of AML patients with chromosomal translocations involving CBF, PML-RAR alpha, HOX, or ETS transcription factor (TF) gene families. Rare chromosomal abnormalities, t(16;21) and t(7; 11), were also found. This study represents the first series to demonstrate the coexistence of known and novel AML1 mutations with different TF gene mutations. Although the occurrence of two TF gene mutations may appear unnecessary, the possible synergistic mechanism between different TF gene families cannot be excluded and needs to be further explored.
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