Journal
RNA
Volume 13, Issue 6, Pages 803-810Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.487907
Keywords
codon redefinition; recoding; ribosome; picorna; 2A; StopGo
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Funding
- NIGMS NIH HHS [R01 GM071853, GM079523, R01 GM079523, GM071853] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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When a eukaryotic mRNA sequence specifying an amino acid motif known as 2A is directly followed by a proline codon, two nonoverlapping proteins are synthesized. From earlier work, the second protein is known to start with this proline codon and is not created by proteolysis. Here we identify the C-terminal amino acid of an upstream 2A-encoded product from Perina nuda picorna-like virus that is glycine specified by the last codon of the 2A-encoding sequence. This is an example of recoding where 2A promotes unconventional termination after decoding of the glycine codon and continued translation beginning with the 39 adjacent proline codon.
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