Stereochemistry and construction of tetrasubstituted chiral carbon Centers in intramolecular Pd-catalyzed 1,3-chirality transfer reactions

A Pd-II-catalyzed cyclization for the construction - from chiral allylic alcohols - of tetrahydropyrans containing tetrasubstituted chiral carbons proceeded stereospecifically by 1,3-chirality transfer through a syn-S(N)2' type process. The chiral 2,2,6-trisubstituted tetrahydropyrans 5 and spiro hydropyrans 6 were obtained in high yields under mild reaction conditions. ((c) Wiley-VCH Verlag GmbH & Co.