Journal
CANCER AND METASTASIS REVIEWS
Volume 26, Issue 2, Pages 291-298Publisher
SPRINGER
DOI: 10.1007/s10555-007-9060-4
Keywords
tumor; hypoxia; hypoxia-inducible factor; metabolism; tumor bioenergetic
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Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells. In this review, the roles of hypoxia, the hypoxia inducible factors, oncogenes and tumor suppressors in metabolic adaptation of tumors are discussed. These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers.
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