Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 27, Issue 6, Pages 1108-1128Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/sj.jcbfm.9600410
Keywords
inhalational anesthesia; neuroprotection; perioperative stroke; preconditioning
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Funding
- NINDS NIH HHS [P01 NS049210, R01 NS054684-01, R01 NS054684, NS20020, NS49210, P01 NS020020] Funding Source: Medline
- NINR NIH HHS [R01 NR003521, R01 NR003521-15] Funding Source: Medline
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This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.
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