Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 12, Pages 29357-29369Publisher
MDPI
DOI: 10.3390/ijms161226172
Keywords
IL-18; psoriasis; atopic dermatitis; urticaria; contact dermatitis; alopecia areata; drug eruption; lupus erythematosus; fibrosis; graft-versus-host disease; skin tumor; skin disease
Funding
- Basic Science Research program through National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012046972]
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Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.
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