Journal
THROMBOSIS AND HAEMOSTASIS
Volume 97, Issue 6, Pages 880-883Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH07-02-0115
Keywords
venous thromboembolism; P-selectin; recurrence; risk factor
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The clinical relevance of high P-selectin levels in venous thrombosis is unknown.We prospectively followed 544 patients with first unprovoked venous thromboembolism (VTE) after cessation of anticoagulation and evaluated P-selectin as a risk factor of recurrent VTENTE recurred in 63 (12%) patients. Patients with recurrence had significantly higher P-selectin levels than those without (45.8 mg/dl +/- 16.4 vs. 40.1 mg/dl +/- 13.3; p = 0.006). After four years,the probability of recurrence was 20.6% (95% confidence interval [Cl] 12.6-28.5) among patients with P-selectin values above the 75(th) percentile of the patient population and was 10.8% (95% Cl 7.2-14.3) among patients with lower values (p = 0.046). Compared to patients with low P-selectin, adjusted risk of recurrence was 1.7-fold (95% Cl 1.0-2.9, p = 0.045) increased among patients with P-selectin levels exceeding the 75(th) percentile.We conclude that high circulating P-selectin is a risk factor of recurrent VTE.
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