Journal
SEMINARS IN IMMUNOLOGY
Volume 19, Issue 3, Pages 197-205Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.02.003
Keywords
itch; ubiquitin; E3 ligase; T helper type 2; Jun proteins; anergy; asthma
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Funding
- NIAID NIH HHS [R01 AI078272, R01 AI062969-01A2, R01 AI078272-01A1, R01 AI062969] Funding Source: Medline
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Tagging a small molecule ubiquitin to a protein substrate, or protein ubiquitination, plays an important role in the immune responses. This process is catalyzed by a cascade of enzymatic reactions, with the E3 ubiquitin ligases being the critical enzymes that determine the specificity of substrate recognition. The E3 ligase Itch was identified from a mutant mouse which displays skin scratching and abnormal immune disorders. In the past few years, much progress has been made in our understanding of Itch-promoted protein ubiquitination, modulation of its ligase activity by upstream kinases, and the kinase-ligase interaction in T cell differentiation and tolerance induction. (C) 2007 Elsevier Ltd. All rights reserved.
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