Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 8, Pages 17668-17681Publisher
MDPI
DOI: 10.3390/ijms160817668
Keywords
tanshinone; pyrrolidine; antibacterial; reactive oxygen species (ROS); membrane
Funding
- Interdisciplinary Cooperation Team Program for Science and Technology Innovation of Chinese Academy of Sciences Science
- National Natural Science Foundation of China (NSFC) [31270860]
- Program for New Century Excellent Talents in University [NCET-13-0480]
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In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents.
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