Journal
UROLOGY
Volume 69, Issue 6, Pages 1165-1169Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urology.2007.02.039
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Objectives To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe. Methods We performed a hospital-based case-control study with 134 prostate cancer patients and 134 cancer-free, age-matched control subjects. Epidemiologic data were collected using a standard questionnaire. Logistic regression was used to estimate odds ratios (ORs) and compute confidence intervals (Cls). Genotypes were determined by multiplex polymerase chain reaction. Results The frequency of the GSTM1-positive genotype was 81% in patients and 73% in control Subjects, with an adjusted OR of 1.4 (95% CI 0.7 to 2.5). The frequency of the GSTT1-positive genotype was 78% in patients and 63% in control subjects, with an adjusted OR of 2.6 (95% CI 1.4 to 4.9). Conclusions A functional GSTT1 polymorphism may be associated with prostate cancer susceptibility in a Caribbean Population of African descent.
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