Journal
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 19, Issue 3, Pages 326-330Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.neuropsych.19.3.326
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In vitro data suggest valproate activates HIV replication. This study prospectively assesses whether divalproex sodium causes an increase in HIV replication in patients. Eight participants had their HIV viral load measured over approximately 1 month. The largest increases in viral load occurred in patients without antiretroviral medication. No patients had an increase in Log(10) HIV viral load >= 0.5. Further study is needed to understand implications.
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