Related references
Note: Only part of the references are listed.Functions and characteristics of PINK1 and Parkin in cancer
Satoru Matsuda et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2015)
Poly-ADP-ribosylation signaling during DNA damage repair
Barbara Golia et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2015)
Lipid Metabolism, Apoptosis and Cancer Therapy
Chunfa Huang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy
D. J. Roberts et al.
CELL DEATH AND DIFFERENTIATION (2015)
p62/SQSTM1 synergizes with autophagy for tumor growth in vivo
Huijun Wei et al.
GENES & DEVELOPMENT (2014)
mTOR and autophagy: A dynamic relationship governed by nutrients and energy
E. A. Dunlop et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
Kai Kaarniranta et al.
AUTOPHAGY (2013)
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
Munehiro Kitada et al.
CLINICAL SCIENCE (2013)
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
Daniela Kenzelmann Broz et al.
GENES & DEVELOPMENT (2013)
UVC-Induced Mitochondrial Degradation via Autophagy Correlates with mtDNA Damage Removal in Primary Human Fibroblasts
Amanda S. Bess et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2013)
Treatment of Triple-Negative Breast Cancer Using Anti-EGFR-Directed Radioimmunotherapy Combined with Radiosensitizing Chemotherapy and PARP Inhibitor
Fares Al-Ejeh et al.
JOURNAL OF NUCLEAR MEDICINE (2013)
Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling
K. Ted Thurn et al.
MOLECULAR CANCER THERAPEUTICS (2013)
Targeting autophagy as a potential therapeutic approach for melanoma therapy
He Liu et al.
SEMINARS IN CANCER BIOLOGY (2013)
Pro-tumorigenic function of autophagy in mammary oncogenesis
Huijun Wei et al.
AUTOPHAGY (2012)
UVRAG At the crossroad of autophagy and genomic stability
Zhen Zhao et al.
AUTOPHAGY (2012)
Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J. Klionsky et al.
AUTOPHAGY (2012)
Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1
Jung-Hoon Yoon et al.
BIOCHEMICAL PHARMACOLOGY (2012)
The incredible ULKs
Sebastian Alers et al.
CELL COMMUNICATION AND SIGNALING (2012)
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy
Jose Manuel Rodriguez-Vargas et al.
CELL RESEARCH (2012)
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
Xin Luo et al.
GENES & DEVELOPMENT (2012)
Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death
Li-Hsin Chen et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy
Morten Scheibye-Knudsen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
J. Ross Chapman et al.
MOLECULAR CELL (2012)
DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging
Pierre Boesch et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy
Mantong Zhao et al.
CELL METABOLISM (2011)
Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
Ravi K. Amaravadi et al.
CLINICAL CANCER RESEARCH (2011)
Autophagy in Tumor Suppression and Cancer Therapy
Che-Pei Kung et al.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2011)
Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts
David Cotan et al.
FASEB JOURNAL (2011)
Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges
Peter T. Simpson et al.
HUMAN PATHOLOGY (2011)
Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription
Ramkumar Rajendran et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)
Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents
Heekyong Bae et al.
MOLECULAR CANCER RESEARCH (2011)
Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase 1
Madhu Dyavaiah et al.
MOLECULAR CANCER RESEARCH (2011)
DNA damage and autophagy
Humberto Rodriguez-Rocha et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)
Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
Alberto Valbuena et al.
PLOS ONE (2011)
Cetuximab Augments Cytotoxicity with Poly (ADP-Ribose) Polymerase Inhibition in Head and Neck Cancer
Somaira Nowsheen et al.
PLOS ONE (2011)
ATM engages the TSC2/mTORC1 signaling node to regulate autophagy
Angela Alexander et al.
AUTOPHAGY (2010)
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
Sven Geisler et al.
AUTOPHAGY (2010)
SIRT1 and p53, effect on cancer, senescence and beyond
Jingjie Yi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
The AMPK-FoxO3A axis as a target for cancer treatment
Fulvio Chiacchiera et al.
CELL CYCLE (2010)
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
Nirmala Hariharan et al.
CIRCULATION RESEARCH (2010)
The role of the Atg1/ULK1 complex in autophagy regulation
Noboru Mizushima
CURRENT OPINION IN CELL BIOLOGY (2010)
Nix is a selective autophagy receptor for mitochondrial clearance
Ivana Novak et al.
EMBO REPORTS (2010)
Mitochondria in cell death
Melissa J. Parsons et al.
ESSAYS IN BIOCHEMISTRY: MITOCHONDRIAL FUNCTION (2010)
Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Discovery of a Novel Function for Human Rad51 MAINTENANCE OF THE MITOCHONDRIAL GENOME
Jay M. Sage et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming
Wen-Xing Ding et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Identification of an Autophagy Defect in Smokers' Alveolar Macrophages
Martha M. Monick et al.
JOURNAL OF IMMUNOLOGY (2010)
Autophagy and the Integrated Stress Response
Guido Kroemer et al.
MOLECULAR CELL (2010)
The DNA Damage Response: Making It Safe to Play with Knives
Alberto Ciccia et al.
MOLECULAR CELL (2010)
Mechanisms of dealing with DNA damage in terminally differentiated cells
P. Fortini et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2010)
Chronic inflammation and mutagenesis
Lynnette R. Ferguson
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2010)
Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
F. Al-Ejeh et al.
ONCOGENE (2010)
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Cristofol Vives-Bauza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Angela Alexander et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PML Nuclear Bodies
Valerie Lallemand-Breitenbach et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
mTOR's role in ageing: protein synthesis or autophagy?
Sarah L. Hands et al.
AGING-US (2009)
To die or to live The dual role of poly (ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage
Qing Huang et al.
AUTOPHAGY (2009)
PARP-1 is involved in autophagy induced by DNA damage
Jose Antonio Munoz-Gomez et al.
AUTOPHAGY (2009)
Coenzyme Q deficiency triggers mitochondria degradation by mitophagy
Angeles Rodriguez-Hernandez et al.
AUTOPHAGY (2009)
DNA Repair in Mammalian Cells
A. P. M. Eker et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria
Nadja C. de Souza-Pinto et al.
DNA REPAIR (2009)
ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
Ian G. Ganley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
Nao Hosokawa et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Khong Bee Kang et al.
MOLECULAR CANCER (2009)
A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability
Renee D. Paulsen et al.
MOLECULAR CELL (2009)
The DNA-damage response in human biology and disease
Stephen P. Jackson et al.
NATURE (2009)
Midbody ring disposal by autophagy is a post-abscission event of cytokinesis
Christian Pohl et al.
NATURE CELL BIOLOGY (2009)
MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
Jan H. J. Hoeijmakers
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Regulation of the aging process by autophagy
Antero Salminen et al.
TRENDS IN MOLECULAR MEDICINE (2009)
A dual role of p53 in the control of autophagy
Ezgi Tasdemir et al.
AUTOPHAGY (2008)
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
M. A. Qadir et al.
BREAST CANCER RESEARCH AND TREATMENT (2008)
Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy
Manuel Rieber et al.
CANCER BIOLOGY & THERAPY (2008)
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
Anja Apel et al.
CANCER RESEARCH (2008)
Mechanisms of neurodegeneration in Huntington's disease
Joana M. Gil et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
Marie W. Wooten et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Mitochondrial alterations in Parkinson's disease: new clues
Miquel Vila et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Eisuke Itakura et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Functional interaction between FOXO3a and ATM regulates DNA damage response
Wen-Bin Tsai et al.
NATURE CELL BIOLOGY (2008)
ATR: an essential regulator of genome integrity
Karlene A. Cimprich et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
Qiming Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline
Althea Elliott et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
The DNA damage response: Ten years after
J. Wade Harper et al.
MOLECULAR CELL (2007)
FoxO3 controls autophagy in skeletal muscle in vivo
Cristina Mammucari et al.
CELL METABOLISM (2007)
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
Yoshinori Takahashi et al.
NATURE CELL BIOLOGY (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
Vassiliki Karantza-Wadsworth et al.
GENES & DEVELOPMENT (2007)
AMP-activated protein kinase -: A universal regulator of autophagy?
Maria Hoyer-Hansen et al.
AUTOPHAGY (2007)
Selective degradation of mitochondria by mitophagy
Insil Kim et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Autophagy suppresses tumor progression by limiting chromosomal instability
Robin Mathew et al.
GENES & DEVELOPMENT (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka et al.
SCIENCE (2007)
Central role of p53 in the suntan response and pathologic hyperpigmentation
Rutao Cui et al.
CELL (2007)
DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells
M. Katayama et al.
CELL DEATH AND DIFFERENTIATION (2007)
Autophagosome-lysosome fusion depends on th pH in acidic compartments in CHO cells
Akinori Kawai et al.
AUTOPHAGY (2007)
Signal integration and diversification through the p62 scaffold protein
Jorge Moscat et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
Ravi K. Amaravadi et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
DRAM links autophagy to p53 and programmed cell death
Diane Crighton et al.
AUTOPHAGY (2007)
Apoptosis: A review of programmed cell death
Susan Elmore
TOXICOLOGIC PATHOLOGY (2007)
Autophagy delays apoptotic death in breast cancer cells following DNA damage
M. J. Abedin et al.
CELL DEATH AND DIFFERENTIATION (2007)
Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC-mTOR signaling pathways
Boyi Gan et al.
JOURNAL OF CELL BIOLOGY (2006)
Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
Nele Festjens et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
Diane Crighton et al.
CELL (2006)
Poly(ADP-ribose):: novel functions for an old molecule
Valerie Schreiber et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
Chengyu Liang et al.
NATURE CELL BIOLOGY (2006)
The multifaceted mismatch-repair system
J Jiricny
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
DNA damage-induced cell death by apoptosis
Wynand P. Roos et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Dissecting p53-dependent apoptosis
J. E. Chipuk et al.
CELL DEATH AND DIFFERENTIATION (2006)
Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast
M Priault et al.
CELL DEATH AND DIFFERENTIATION (2005)
BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis
SA Martin et al.
CANCER RESEARCH (2005)
Mechanism of cell cycle regulation by FIP200 in human breast cancer cells
ZK Melkoumian et al.
CANCER RESEARCH (2005)
Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
BY Gan et al.
JOURNAL OF CELL BIOLOGY (2005)
The coordinate regulation of the p53 and rnTOR pathways in cells
ZH Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Autophagy: Dual roles in life and death?
EH Baehrecke
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide
I Banmeyer et al.
FEBS LETTERS (2005)
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice
S Espejel et al.
EMBO REPORTS (2004)
Role of AIF in caspase-dependent and caspase-independent cell death
SP Cregan et al.
ONCOGENE (2004)
Toxic proteins released from mitochondria in cell death
X Saelens et al.
ONCOGENE (2004)
Role of DNA-PK in the cellular response to DNA double-strand breaks
S Burma et al.
DNA REPAIR (2004)
Autophagy: Many paths to the same end
AM Cuervo
MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)
Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium
VN Reddy et al.
EXPERIMENTAL EYE RESEARCH (2004)
Mechanisms of chaperone-mediated autophagy
AE Majeski et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Death by design: apoptosis, necrosis and autophagy
AL Edinger et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis
YP Gu et al.
FEBS LETTERS (2004)
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
A Sancar et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2004)
Recombination of human mitochondrial DNA
Y Kraytsberg et al.
SCIENCE (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
CJ Bakkenist et al.
NATURE (2003)
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
S Espejel et al.
EMBO JOURNAL (2002)
Regulation of focal adhesion kinase by a novel protein inhibitor FIP200
S Abbi et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
SW Yu et al.
SCIENCE (2002)
Formation of the ∼350-kDa Apg12-Apg5•Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
A Kuma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
H Tran et al.
SCIENCE (2002)
Purification and characterization of human DNA damage checkpoint Rad complexes
LA Lindsey-Boltz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The mitochondrial permeability transition initiates autophagy in rat hepatocytes
SP Elmore et al.
FASEB JOURNAL (2001)
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
A Kihara et al.
JOURNAL OF CELL BIOLOGY (2001)
Cell biology - Autophagy as a regulated pathway of cellular degradation
DJ Klionsky et al.
SCIENCE (2000)
A ubiquitin-like system mediates protein lipidation
Y Ichimura et al.
NATURE (2000)
Tor-mediated induction of autophagy via an Apg1 protein kinase complex
Y Kamada et al.
JOURNAL OF CELL BIOLOGY (2000)
Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting
SV Scott et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Rfc5 in cooperation with Rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae
T Naiki et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Suppression of Pyk2 kinase and cellular activities by FIP200
H Ueda et al.
JOURNAL OF CELL BIOLOGY (2000)
A novel Rad24 checkpoint protein complex closely related to replication factor C
CM Green et al.
CURRENT BIOLOGY (2000)
Repair of endogenous DNA damage
T Lindahl et al.
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (2000)
Share Paper
