Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 6, Pages 984-988Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0700772
Keywords
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Funding
- FIC NIH HHS [U01 TW006634-01, U01 TW006634, 1-U01 TW006634-01] Funding Source: Medline
- NCI NIH HHS [U19 CA052955-160002, CA52955, U19 CA052955] Funding Source: Medline
- NIEHS NIH HHS [P30 ES00210, P30 ES000210] Funding Source: Medline
- NIGMS NIH HHS [R01 GM063554-01, R01 GM063554, GM63554] Funding Source: Medline
- NINDS NIH HHS [R01 NS053398] Funding Source: Medline
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As part of the Panama International Cooperative Biodiversity Groups (ICBG) project, two new (2, 4) and two known (1, 3) linear alkynoic lipopeptides have been isolated from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. Carmabin A (1), dragomabin (2), and dragonamide A (3) showed good antimalarial activity (IC50 4.3, 6.0, and 7.7 mu M, respectively), whereas the nonaromatic analogue, dragonamide B (4), was inactive. The planar structures of all four compounds were determined by NMR spectroscopy in combination with mass spectrometry, and their stereoconfigurations were established by chiral HPLC and by comparison of their optical rotations and NMR data with literature values.
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