Journal
SEMINARS IN IMMUNOLOGY
Volume 19, Issue 3, Pages 162-172Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.02.008
Keywords
anergy; proliferation; CD4+T cells; mTOR
Categories
Funding
- NIAID NIH HHS [P01 AI035296-090002, P01 AI035296] Funding Source: Medline
- NIGMS NIH HHS [R01 GM054706-08, R01 GM054706] Funding Source: Medline
Ask authors/readers for more resources
Several events control the activation, proliferation, and the continued Ag responsiveness of naive and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed. (C) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available