Journal
ANALYTICAL METHODS
Volume 5, Issue 6, Pages 1623-1628Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ay26067d
Keywords
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Funding
- National Science Foundation [CHE-0957784]
- National Institutes of Health [1R01DK071801]
- H. I. Romnes Faculty Research Fellowship
- NIH [NRSA T32 EB011434]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [957784] Funding Source: National Science Foundation
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Nanostructure-initiator mass spectrometry (NIMS) is a recently developed matrix-free laser desorption/ionization technique that has shown promise for peptide analyses. It is also useful in mass spectrometric imaging (MSI) studies of small molecule drugs, metabolites, and lipids, minimizing analyte diffusion caused by matrix application. In this study, NIMS and matrix-assisted laser desorption/ionization (MALDI) MSI of a crustacean model organism Cancer borealis brain were compared. MALDI was found to perform better than NIMS in these neuropeptide imaging experiments. Twelve neuropeptides were identified in MALDI MSI experiments whereas none were identified in NIMS MSI experiments. In addition, lipid profiles were compared using each ionization method. Both techniques provided similar lipid profiles in the m/z range 700-900.
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