Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1771, Issue 6, Pages 727-736Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2007.04.002
Keywords
PITP; membrane trafficking; Sec14p; PITPs; lipids; signaling; genetics; polarized membrane growth
Funding
- NIGMS NIH HHS [R01 GM044530, R01 GM044530-16] Funding Source: Medline
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A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal resolution. In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control. Herein, we review the emerging evidence regarding the roles of Sec14-like phosphatidylinositol transfer proteins (PITPs) in the action of intracellular signaling networks; particularly as these relate to membrane trafficking. Finally, we explore developing ideas regarding how Sec14-like PITPs execute biological function. As See 14-like proteins define a protein superfamily with diverse lipid (or lipophile) binding capabilities, it is likely these under-investigated proteins will be ultimately demonstrated as a ubiquitously important set of biological regulators whose functions influence a large territory in the signaling landscape of eukaryotic cells. (c) 2007 Elsevier B.V. All rights reserved.
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