Journal
ANALYTICAL METHODS
Volume 5, Issue 3, Pages 648-652Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ay26176f
Keywords
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Funding
- National Natural Science Foundation of China [21175076, 41171178]
- Scientific Research Fund of the First Institute of Oceanography, SOA [2012T07]
- Scientific Special Expenditure for Non-profit Public Industry of State Oceanic Administration [201105020]
- Basic Research Program of Qingdao [11-2-4-3-(4)-jch]
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A novel, simple, and rapid colorimetric strategy is proposed based on the aggregation of gold nanoparticles (AuNPs) induced by the unfolding of G-quadruplex (G4) in the presence of silver ions (Ag+). AuNPs to which compact G4 structures were attached had higher stability toward salt-induced aggregation of AuNPs than those on which random coil single-stranded DNA (ssDNA) structures were anchored. In the Ag+-free system, AuNPs remained mono-dispersed. In contrast, upon addition of Ag+, the G4 structure unfolded, inducing aggregation of the AuNPs. The linear range of the as-established colorimetric assay for Ag+ was from 2.0 x 10(-8) M to 2.0 x 10(-6) M, with a detection limit of approximately 7 nM. Additionally, the colorimetric sensor showed good selectivity toward Ag+. The proposed method offers a new assay for metal ion-mediated aggregation-based colorimetric sensing and may pave a new way for heavy metal ions detection.
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