Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 11, Pages 6106-6110Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00070-07
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Funding
- NEI NIH HHS [P30 EY002377, F32 EY016316, P30EY002377, R01 EY006311, R01EY006311, F32EY016316] Funding Source: Medline
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Recent studies have explored the chromatin structures associated with the herpes simplex virus type 1 (HSV-1) genome during latency, particularly with regard to specific histone tail modifications such as acetylation and dimethylation. The objective of our present study was to develop a rapid systemic method of in vivo HSV-1 reactivation to further explore the changes that occur in the chromatin structures associated with HSV-1 at early time points after the initiation of HSV reactivation. We present a uniform, rapid, and reliable method of in vivo HSV-1 reactivation in mice that yields high reactivation frequencies (75 to 100%) by using sodium butyrate, a histone deacetylase inhibitor, and demonstrate that the reactivating virus can be detected at the original site of infection.
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