Journal
ANALYTICAL METHODS
Volume 4, Issue 4, Pages 895-897Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ay25034a
Keywords
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Funding
- National Natural Science Foundation of China [90606003, 21190044, 21175035]
- National Basic Research Program [2011CB911002]
- International Science & Technology Cooperation Program of China [2010DFB30300]
- Program for New Century Excellent Talents in University [NCET-09-0338]
- Hunan Provincial Natural Science Foundation of China [10JJ7002]
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A single labeled fluorescence probe was designed based on the efficient quenching ability of a G-quadruplex instead of traditional quenchers. Using this probe, we have investigated the quenching ability of a G-quadruplex and developed a new approach to analyze mercury ions and cysteine with high specificity and sensitivity. Owing to the high quenching ability of the G-quadruplex and the fidelity of the thymine-Hg2+-thymine binding motif, this approach can detect 4.0 nM mercury ions, which is lower than the 10 nM US EPA limit in drinking water.
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