Journal
FUTURE MICROBIOLOGY
Volume 2, Issue 3, Pages 297-307Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/17460913.2.3.297
Keywords
AmpC; carbapenem; cefepime; cephalosporin; extended-spectrum AmpC beta-lactamases; extended-spectrum cephalosporinase
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Extended-spectrum AmpC beta-lactamases of Enterobacteriaceae, which are chromosomally or plasmid-encoded, possess structural modifications in the vicinity of the active site compared with their progenitors. They display an increased catalytic efficiency against extended-spectrum beta-lactams, such as ceffazidime, cefotaxime, cefepime, cefpirome and, in some cases, also against imipenem. An overview of the molecular and biochemical characterization of this recently identified mechanism of resistance to beta-lactams is provided as well as its prevalence and possible clinical significance.
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