Journal
BLOOD
Volume 109, Issue 11, Pages 4806-4809Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-09-047449
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Funding
- MRC [G0600681, G108/485] Funding Source: UKRI
- Medical Research Council [G108/485, G0600681] Funding Source: researchfish
- Medical Research Council [G108/485, G0600681] Funding Source: Medline
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The G6B cell-surface receptor, which contains a single Ig-like domain, has been shown to bind to SHP-1 and SHIP-2 after phosphorylation of 2 immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail, classifying this protein as a new member of the family of inhibitory receptors. In this study, we demonstrate by real-time polymerase chain reaction (PCR) and Western-blot analysis that G6B is expressed on platelets. Cross-linking of G6B with polyclonal antisera has a significant inhibitory effect on platelet aggregation and activation by agonists such as ADP and collagen-related peptide (CRP). This inhibitory function of G6B appears to operate in a calcium-independent manner. Our results suggest that G6B represents a novel inhibitory receptor found on the surface of platelets and that it could be an antithrombotic drug target.
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