4.6 Article

A new labelling reagent for glycans analysis by capillary electrophoresis-mass spectrometry

Journal

ANALYTICAL METHODS
Volume 4, Issue 2, Pages 357-359

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ay05741g

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Funding

  1. National Natural Science Foundation of China [30890142, 20975007]
  2. MOST, China [2009CB320305]

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In this work, a novel labelling reagent with multi-charges was designed and developed for glycans capillary electrophoresis-mass spectrometry (CE-MS) analysis. Glycans labelled with this reagent have multiple charges. The results showed that the separation efficiencies of glycans were improved and the sensitivities of large glycans were enhanced more than 10 fold.

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