Journal
ARCHIVES OF VIROLOGY
Volume 152, Issue 6, Pages 1201-1208Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-006-0934-5
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Funding
- Wellcome Trust [076330, 071588, 071588/Z/03/Z] Funding Source: Medline
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A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.
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