Journal
NATURE REVIEWS CANCER
Volume 7, Issue 6, Pages 415-428Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2131
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The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
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