Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 19, Issue 3, Pages 301-308Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.04.011
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Funding
- NIAID NIH HHS [AI044432, AI040127] Funding Source: Medline
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Killer lymphocytes release perforin and granzymes from cytotoxic granules into the immunological synapse to destroy target cells as a critical mechanism. in the defense against viruses and cancer. Perforin, a Ca2+-dependent pore-forming protein that multimerizes in membranes, delivers granzymes into the target cell cytosol. The original model for perforin (acting by forming a cell membrane channel through which granzymes pass) does not fit the experimental data. Recently, an alternative model has been proposed that involves active target cell collaboration with perforin to deliver granzymes and direct the target cell to an apoptotic, rather than necrotic, death.
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