Journal
ANALYTICAL METHODS
Volume 3, Issue 8, Pages 1729-1736Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ay05107e
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Funding
- National Institute on Drug Abuse, NIH
- Office of National Drug Control Policy (ONDCP)
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Cell membranes are made up of a mixture of glycerolipids, sphingolipids, gangliosides and cholesterol. Lipids play important roles in a cell's life. However many of their functions have still to be discovered. In the present work, we describe an efficient, easy and rapid methodology to accurately localize phosphatidylcholines and sphingomyelins from a single coronal rat brain section in the cerebrum area. Matrix assisted laser desorption/ionization (MALDI) mass spectrometry was used to profile and image lipids. The best resolved structure was 25-50 mu m in the hippocampus.
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