Journal
TRENDS IN MICROBIOLOGY
Volume 15, Issue 6, Pages 241-251Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2007.04.005
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01 AI51472] Funding Source: Medline
Ask authors/readers for more resources
Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-dependent, T3S-mediated chlamydial growth and late differentiation, suggest that chlamydiae contained in small non-fusogenic inclusions will persist. Here, we further discuss the model in the context of in vitro-persistent, stress-induced aberrantly enlarged forms and of recent studies using small molecule inhibitors of T3S. A general mechanism is emerging whereby both early- and mid-cycle T3S-mediated activities and late T3S inactivation upon detachment of chiamydiae from the inclusion membrane are crucial for chlamydial intracellular development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available