Journal
BIOMETALS
Volume 20, Issue 3-4, Pages 453-465Publisher
SPRINGER
DOI: 10.1007/s10534-006-9071-6
Keywords
TonB; outer membrane; iron transport; B-group colicins; crystal and NMR structures
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Funding
- NIGMS NIH HHS [R01 GM042146] Funding Source: Medline
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The TonB system of Escherichia coli (and most other Gram-negative bacteria) is distinguished by its importance to iron acquisition, its contribution to bacterial pathogenesis, and a unique and mysterious mechanism of action. This system somehow gathers the potential energy of the cytoplasmic membrane (CM) proton gradient and delivers it to active transporters in the outer membrane (OM). Our understanding of this system is confounded by the challenge of reconciling often contradictory in vivo and in vitro studies that are presented in this review.
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