Journal
TRENDS IN NEUROSCIENCES
Volume 30, Issue 6, Pages 284-291Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2007.03.012
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Funding
- NIA NIH HHS [AG 022074] Funding Source: Medline
- NINDS NIH HHS [NS 045191, NS 039074] Funding Source: Medline
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Learning and memory depend on persistent changes in synaptic strength that require neuronal gene expression. An unresolved question concerns the mechanisms by which activity at synapses is transduced into a nuclear transcriptional response. In the prevailing view, N-methyl-D-aspartate (NMDA)- and alpha-amino-3-hydroxy5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors have distinct roles in controlling synaptic strength: AMPA receptors effect short-term changes in synaptic strength, whereas NMDA receptors regulate genes that are required for the long-term maintenance of these changes. Here, we review recent data on the roles of these two types of receptor in activity-dependent gene expression. We discuss evidence that signals from NIVIDA receptors and AMPA receptors are integrated to specify transcriptional responses for particular plasticity related genes.
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