Journal
BIOMOLECULAR ENGINEERING
Volume 24, Issue 2, Pages 169-177Publisher
ELSEVIER
DOI: 10.1016/j.bioeng.2007.03.002
Keywords
posttranslational modification; sulfation; nitrosylation; lipidation; protein oxidation
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Posttanslational modifications of proteins possess key functions in the regulation of various cellular processes. While they facilitate fast, location-specific and transient reactions to changing conditions in the first place they enhance the already high complexity of a cellular proteome by orders of magnitude. Furthermore, they can utterly alter the properties of the modified protein, thus making a timely analysis even more difficult. While several standardized methods for the analysis of protein phosphorylation and glycosylation have been established most other modifications require tailor-made solutions for a comprehensive analysis. Therefore, we will provide guidelines for the analysis of some important posttranslational modifications that are underrepresented in contemporary literature. (c) 2007 Published by Elsevier B.V.
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