Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 29, Issue 2, Pages 151-162Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-007-0071-6
Keywords
pregnancy; preeclampsia; placenta; cytokines; inflammatory response
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Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi- allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy. The placenta is an integral component of this inflammatory response as it actively produces a variety of cytokines and immunomodulatory hormones. In preeclampsia, a lifethreatening disorder of pregnancy that is characterized by widespread damage and dysfunction of the maternal endothelium, placental oxidative stress and aberrant cytokine expression induces an exaggerated maternal systemic inflammatory response to pregnancy.
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