Journal
NATURE REVIEWS CANCER
Volume 7, Issue 6, Pages 409-413Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2145
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Recent studies have shown that three major tumour-suppressor proteins undergo monoubiquitylation-mediated nuclear-cytoplasmic shuttling. Importantly, this mechanism has consequences for cancer and implies that proper localization is central to the function of tumour suppressors. This Progress article highlights recent efforts demonstrating that monoubiquitylation coupled to nuclear-cytoplasmic shuttling might be a novel regulatory mechanism that directly influences the function of tumour suppressors.
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