Journal
ANALYTICAL LETTERS
Volume 46, Issue 14, Pages 2279-2289Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00032719.2013.796557
Keywords
Bacteriostasis; Balofloxacin; Drug carrier; Graphene oxide
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Funding
- National Natural Science Foundation of China [21275059, 21175049]
- Fundamental Research Funds for the Central Universities [JB-ZR1118, 1215]
- Natural Science Foundation of Fujian Province [2011J01044]
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A novel graphene oxide-balofloxacin nanocomposite was synthesized, and the loading and release behavior of fluorescent antibacterial balofloxacin on graphene oxide was investigated. The surface morphologies of the nanocomposite were evaluated using transmission electron microscopy and fluorescence microscopy, and the amount of balofloxacin loaded on graphene oxide reached 160.3mg/g at the initial balofloxacin concentration of 8.51 mu g/ml. The graphene oxide and balofloxacin nanocomposite showed the advantage of a longer release time than many current developed nanoscaled drug carriers, which was probably due to the hydrogen bonding interaction between graphene oxide and balofloxacin. The study of the release liquid of e. coli in vitro bacteriostasis suggests that the graphene oxide-balofloxacin nanocomposite has a superior effect against e. coli.
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