Journal
VIRUS RESEARCH
Volume 126, Issue 1-2, Pages 282-287Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2007.02.018
Keywords
CD4(+) T-cells; escape; influenza A virus
Categories
Funding
- NIH HHS [DP1-OD000490-01] Funding Source: Medline
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Influenza virus-specific CD4(+) T-helper cells were cloned that recognized a virus strain isolated in 1981, but that failed to recognize more recent strains. The HLA-DR*1601-restricted epitope recognized was located in the hemagglutinin (HA(99-113)) and the naturally occurring A -> V substitution at position 106 was responsible for abrogating the recognition by HA(99-113)-specific CD4(+) T-cells. This amino acid substitution was found in influenza A/H3N2 viruses that circulated between 1999 and 2005 and did not affect recognition by virus-specific antibodies. It was speculated that influenza viruses could evade recognition by virus-specific CD4(+) T-cells, at least temporarily. (C) 2007 Elsevier B.V. All rights reserved.
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