Journal
ANALYTICAL LETTERS
Volume 45, Issue 2-3, Pages 168-186Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00032719.2011.633188
Keywords
Bioanalysis; Biomedical; Electrochemical; Enzyme biosensors; Optical; Review
Categories
Funding
- NSF [0954919]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0954919] Funding Source: National Science Foundation
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The need for simple, rapid, cost-effective, and portable screening methods has boosted the development of practical biosensors with applications in clinical monitoring, and diagnosis of disease. Compared with traditional analytical methods, enzyme-based bioanalytical devices have several distinct advantages such as high sensitivity and specificity, portability, cost-effectiveness, and the possibilities for miniaturization and mass production. Additionally, they can be developed for point-of-care diagnostic testing. This paper reviews recent advances in the development of enzyme biosensors, design characteristics, performances, and applications with a focus on electrochemical and optical sensors. Recent emerging technologies and innovative biosensing designs, such as nanosensors, paper based-sensors, lab-on-a-chip, biochips, and microfluidic devices are discussed. Specific applications in bioanalysis, clinical diagnosis, and pharmacology are discussed.
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