Journal
ANALYTICAL LETTERS
Volume 45, Issue 18, Pages 2717-2727Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00032719.2012.702173
Keywords
Electrochemical sensor; Graphene; Molecularly imprinted; Sensitivity enhancement; Uric acid
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Funding
- National High Technology Research and Development Program of China [2009AA03Z217]
- National Natural Science Foundation of China [20955001, 21275059, 21175049]
- Major Research Plan of National Nature Science Foundation of China [90922028]
- Natural Science Foundation of Fujian Province of China [2011J01049, 2012J01044]
- Fundamental Research Fund for the Central Universities [10QZR13, 11QZR12, JB-ZR1215]
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A highly sensitive uric acid molecularly imprinted electrochemical sensor was prepared by using graphene doped chitosan as the functional matrix and uric acid as the template molecule; a electrodeposition technique was used to form a controllable graphene-chitosan-uric acid composited film on glassy carbon electrode whose uric acid was removed via electrochemical induce elution. Under the optimized preparation and detection conditions, the detection sensitivity of uric acid at graphene doped molecularly imprinted sensor was improved significantly compared with the undoped molecularly imprinted sensor. The mechanisms of sensitivity enhancement were studied by a.c. electrochemical impedance, adsorption model, and chronocoulometry. The observations suggest the effect of sensitivity enhancement resulted from magnified surface area and good electronic conduction of graphene. Additionally, the developed sensor exhibited specific recognition to uric acid against the competitors which consisted of structure liked substances and coexisting interference in blood serum.
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