Journal
SCIENCE
Volume 316, Issue 5829, Pages 1341-1345Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1142382
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Funding
- Intramural NIH HHS [Z01 HG000024, Z01 HG000024-13] Funding Source: Medline
- NHGRI NIH HHS [R01 HG002651-01, R01 HG002651, T32 HG000040, N01 HG065403, HG002651, N01HG65403] Funding Source: Medline
- NHLBI NIH HHS [U01 HL084729, U01 HL084729-01, HL084729] Funding Source: Medline
- NIDA NIH HHS [U54 DA021519-02, U54 DA021519] Funding Source: Medline
- NIDDK NIH HHS [R01 DK072193-04, U01 DK062370, DK072193, R01 DK062370, R01 DK029867, DK062370, R56 DK062370, R01 DK072193, R01 DK062370-04] Funding Source: Medline
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Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10.
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