Journal
ANALYTICAL LETTERS
Volume 44, Issue 5, Pages 908-921Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00032711003790049
Keywords
Alkaline phosphatase; Chitosan; Gold nanoparticles; Immunosensor; Ionic liquid; Prostate specific antigen
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Funding
- National Natural Science Foundation of China [20905041]
- Qingdao University of Science and Technology [0022141]
- Natural Science Foundation of Shandong Province [Q2007B03, J2008B02]
- Scientific and Technical Development Project of Qingdao [07-2-3-11-jch]
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The hybrid film of gold nanoparticles/ionic liquid-chitosan (GNP/IL-Ch) was first prepared by a simple one-step synthesis and used as an efficient immobilization matrix to fabricate an immunosensor. The GNP/IL-Ch film not only prevents the leakage of the IL units, but also produces a well-defined voltammetric signal due to the synergistic effects of the IL units and GNPs. By immobilizing an alkaline phosphatase (ALP)-labeled antibody in GNP/IL-Ch film, a sensitive amperometric immunosensor has been developed for prostate specific antigen (PSA). Under the optimized conditions, the immunosensor exhibits a linear range from 1.0 to 80 ng mL(-1) of PSA.
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