Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 4, Pages 8227-8253Publisher
MDPI
DOI: 10.3390/ijms16048227
Keywords
microRNA; osteogenesis; bone regeneration
Funding
- National Natural Science Foundation of China [31271029, 81170876, 81320108010]
- Science and Technology Commission of Shanghai Municipality [15YF1406800]
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MicroRNAs (miRNAs) are endogenous small noncoding similar to 22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair.
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