Journal
VIRUS RESEARCH
Volume 126, Issue 1-2, Pages 277-281Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2007.02.016
Keywords
HIV; monocyte; macrophage; postentry; uncoating
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Freshly isolated blood monocytes show an early postentry block to in vitro HIV-1 infection. Differentiation into monocyte-derived macrophages (MDMs) is required to allow HIV replication in this cell type. In this study, we investigated whether the resistance of inonocyte to HIV infection stemmed from uncoating defect. Monocyte and MDM lysates induced HIV-1 core uncoating to a comparable degree. This suggests that monocyte lacks a factor(s) essential for viral reverse transcription and/or contains a factor(s) interfering with this step. (C) 2007 Elsevier B.V. All rights reserved.
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