Journal
ANALYTICAL LETTERS
Volume 42, Issue 3, Pages 536-554Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00032710802677084
Keywords
Biological samples; molecularly imprinted polymer; monolithic stationary phase; propranolol
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Funding
- National Natural Science Foundation of China [30672551]
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A propranolol molecule-imprinted monolithic stationary phase (MIMSP) was synthesized by in situ technique. The recognition mechanism of the polymers and the influences of some chromatographic conditions were examined by high-performance liquid chromatography (HPLC). The imprinted polymers showed much higher selectivity for -blockers than the nonimprinted polymers (NIPs) did, which proves the successful preparation of propranolol-imprinted polymers by using an in situ technique. Then, this technique was used to prepare a molecularly imprinted polymer solid-phase extraction column to concentrate propranolol from biological samples. The results showed that the imprinted solid-phase extraction column could selectively enrich and purify propranolol from biological samples, such as plasma.
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